Researchers have discovered a new bacterium, Tomasiella immunophila (T. immunophila), that weakens the immune system in the gut by breaking down secretory immunoglobulin A (SIgA), a crucial antibody that protects mucosal surfaces. This breakdown leads to increased susceptibility to infections and inflammation, potentially contributing to inflammatory and infectious gut diseases like inflammatory bowel disease, Crohn's disease, and ulcerative colitis. The discovery of T. immunophila provides a new understanding of how the gut microbiome can influence immune function and opens exciting avenues for developing therapeutics targeting SIgA manipulation to improve gut health.
Qiuhe Lu, Thomas C. A. Hitch, Julie Y. Zhou, Mohammed Dwidar, Naseer Sangwan, Dylan Lawrence, Lila S. Nolan, Scott T. Espenschied, Kevin P. Newhall, Yi Han, Paul E. Karell, Vanessa Salazar, Megan T. Baldridge, Thomas Clavel, Thaddeus S. Stappenbeck. A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency. Science, 2024; 385 (6716) DOI: 10.1126/science.adk2536
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