This study investigates the effectiveness of photodynamic therapy (PDT) using photodithazine, a topical photosensitizer, and micro-LED treatment on acne bacteria-induced inflammation. A model of acne bacteria-induced inflammation was created using HR-1 mice, which were divided into seven different groups for comparative analysis. The results showed a significant reduction in the severity and number of acne lesions after the PDT treatment compared to control groups that received either LED or photosensitizer alone. Furthermore, the study observed a decrease in the levels of certain biomarkers associated with inflammation and a reduction in inflammatory cells and biomarkers in skin samples post-PDT. The study concludes that PDT using photodithazine and micro-LED technology effectively combats inflammation caused by acne bacteria.
REFERENCE:
Lee SM, Kim SH, Kim Z, Lee JB. Photodynamic Effects of Topical Photosensitizer, Photodithazine Using Micro-LED for Acne Bacteria Induced Inflammation.. Annals of dermatology 36(6):329-340. 2024 Dec DOI: 10.5021/ad.23.157 PMID: 39623608. https://doi.org/10.1002/fsn3.4555
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