This comprehensive review explores the effects of resveratrol, a natural compound found in food such as grapes and peanuts, on nonmelanoma skin cancer (NMSC), the most common form of skin cancer. Resveratrol has shown promising abilities to prevent and fight NMSC through a variety of mechanisms including the induction of apoptosis (cell death), inhibition of cell proliferation, modulation of oxidative stress, and anti-inflammatory activities. It has been found to enhance the effectiveness of traditional chemotherapy agents like 5-fluorouracil by inhibiting the proliferation of cancer cells and inducing apoptosis. Its antioxidant properties may also reduce DNA damage and mutations related to skin cancer by mitigating the impact of reactive oxygen species triggered by UV exposure. The use of advanced delivery systems, like lipid carriers and liposomes, may further enhance the therapeutic effects of resveratrol. However, additional clinical studies are needed to fully understand its effectiveness and safety in humans and to optimize delivery methods for improved bioavailability and therapeutic outcomes.
REFERENCE
Zamanian MY, Shahbazi T, Kazmi SW, Hussien BM, Sharma A, Qasim MT, Hjazi A, Sapaev IB, Nouri Danesh A, Taheri N, Golmohammadi M. Effects of Resveratrol on Nonmelanoma Skin Cancer (NMSC): A Comprehensive Review.. Food science & nutrition 12(11):8825-8845. 2024 Nov DOI: 10.1002/fsn3.4555 PMID: 39620024. https://doi.org/10.1002/fsn3.4555
Content curated by: Dr. Cameron Jones, PhD
Public Health Expert, Fungal Biologist, and Science Communicator
CEO of Biological Health Services, a consultancy and lab specializing in indoor air quality.
Adjunct Faculty at the National Institute of Integrative Medicine, Australia.
Founder, BioMedix & House of Pot, Bangkok
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