The academic paper "The Potential of Cannabis in Managing Inflammatory Bowel Disease and Its Future Perspective" discusses the potential use of cannabis as a complementary therapy for Inflammatory Bowel Disease (IBD), a condition that includes Crohn's disease and ulcerative colitis. Cannabis works by interacting with two receptors, CB1 and CB2, found in the brain, enteric nervous system, gastrointestinal cells, and immune cells, potentially reducing symptoms such as gut motility, secretions, and inflammatory edema. However, the authors note that the small sample size of previous studies makes it hard to definitively conclude its efficacy and safety. They suggest that future research should focus on cannabis derivatives and endocannabinoids to maximize pain relief and minimize psychotropic side effects, and call for larger, long-term, randomized, placebo-controlled trials using standardized cannabinoid compositions.
REFERENCE:
Rauf A, Nisar M, Shaeel M, Athar A, Rehman MMU, Faheem F. The Potential of Cannabis in Managing Inflammatory Bowel Disease and Its Future Perspective.. Cureus 16(10):e71068. 2024 Oct DOI: 10.7759/cureus.71068 PMID: 39624503. https://doi.org/10.7759/cureus.71068
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